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  • 姓名： 张蒙
  • 性别： 男
  • 职称： 项目研究员
  • 职务： 
  • 学历： 博士研究生
  • 电话： 
  • 传真： 
  • 电子邮件： zhangmeng@mail.ipc.ac.cn
  • 通讯地址： 北京市海淀区中关村东路29号
    简　　历：

  • 2011-2013, 得克萨斯大学埃尔帕索分校 (University of Texas at El Paso), 生物信息学, 硕士

    2013-2015, 劳伦斯·伯克利国家实验室分子研究中心 (LBNL, Molecular Foundry), 科研助理

    2016-2022, 加州大学伯克利分校 (University of California, Berkeley), 应用科学与技术, 博士    

    2022-2025, 加州大学伯克利分校定量生物科学研究所 (QB3), 博士后

    2026-至今, 中国科学院理化技术研究所, 项目研究员


    社会任职：
    研究方向：

  • 低温应激下生物大分子动态重排的原位结构解析

    低温相变过程中细胞损伤与保护机制

    发展冷冻电镜单分子原位断层扫描技术


    承担科研项目情况：

  • 低温应激下生物大分子动态重排的原位结构解析， 中国科学院人才项目，200万

    代表论著：

  • 1.  Meng Zhang, Cristhian Cañari-Chumpitaz, Jianfang Liu, Bibiana Onoa, Sinead de Cleir, Enze Cheng, Katherinne I. Requejo, Carlos Bustamante, “Apical localization of RNA polymerases modulates transcription dynamics and supercoiling domains revealed by cryo-ET”, Molecular Cell 2026, 86, 2070-2087

    2.  Meng Zhang, Cesar Díaz-Celis, Bibiana Onoa, Crithian Cañari- Chumpitaz, Katherinne Requejo, K. Jianfang Liu, J, Michael Vien, Evangel Nogales, Gang Ren, Carlos Bustamante. “Molecular Organization of the Early Stages of Nucleosome Phase Separation Visualized by Cryo-Electron Tomography” Molecular Cell 2022, 82, 3000-3014

    3.  Meng Zhang, César Díaz-Celis, Jianfang Liu, Jinhui Tao, Paul D. Ashby, Carlos Bustamante, Gang Ren. “Angle between DNA linker and nucleosome core particle regulates array compaction revealed by individual-particle cryo-electron tomography”, Nat. Commun. 2024, 15, 4395

    4.  Lingli Kong, Jianfang Liu, Meng Zhang (co-first), Zhuoyang Lu, Han Xue Amy Ren, Jiankang Liu, Jinping Li, Wai Li Ling, Gang Ren, “Facile hermetic TEM grid preparation for molecular imaging of hydrated biological samples at room temperature. Nat. Commun. 2023, 14, 5641

    5.  Xiangyang Liua, Jianchun Chua, Sa Xuea, Daquan Wang, Zhuoyang Lu, Meng Zhang (co-first), Yongqi Liu, Xin Xu, Yilin Zhang, Jiangang Long, Lingjie Meng, Jiayin Yuan, Maogang He. “Multitarget Generate Electrolyte Additive for Lithium Metal Batteries”. Adv. Mater., 2025, 2502086

    6.  Meng Zhang, Xue Han, Gang Ren, “A review of molecular structural at the early stages of nucleosome phase separation”. J. Chin. Electron Microsc. Soc, 2024, 43, 1

    7.  Jianfang Liu, Ewan McRae, Meng Zhang, Cody Geary, Ebbe Sloth Andersen, Gang Ren, “Non-averaged single-molecule tertiary structures reveal RNA self-folding through individual-particle cryo-electron tomography”, Nat. Commun. 2024, 15, 9084

    8.  Meng Zhang, Xiaobo Zhai, Jinping Li, John J. Albers, Simona Vuletic, Gang Ren, Structural basis of the lipid transfer mechanism of phospholipid transfer protein (PLTP), BBA-Molecular and Cell Biology of Lipids, 2018, 1863, 1082-1094

    9.  Meng Zhang, Dongsheng Lei, Bo Peng, Mickey Yang, Lei Zhang, M. Art Charles, Kerry-Anne Rye, Ronald M. Krauss, Douglas G. Johns, Gang Ren. “Assessing the mechanisms of cholesteryl ester transfer protein inhibitors”. BBA-Molecular and Cell Biology of Lipids, 2017, 1862, 1606-1617.

    10.   Meng Zhang, River Charles, Huimin Tong, Lei Zhang, Mili Patel, Francis Wang, Matthew J. Rames, Amy Ren, Kerry-Anne Rye, Xiayang Qiu, Douglas G. Johns, M. Arthur Charles & Gang Ren. “HDL surface lipids mediate CETP binding as revealed by electron microscopy and molecular dynamics simulation”. Sci. Rep. 2015, 5, 8741


    获奖及荣誉：
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地址：中国.北京