张锁慧，2010年毕业于中科院理化技术研究所，获理学博士学位，（导师：高云华研究员）。2010年7月至今工作于中科院理化所纳米生物集成技术课题组。研究领域专注于微针经皮给药技术，作为子课题负责人参与了中科院STS项目“聚合物微针给药技术生产工艺研发及应用”，成功建立了聚合物微针经皮给药制剂平台，并与多家企业和研究机构进行合作。在科研方面，已在Acta Pharmaceutica Sinica B、Journal Controlled Release、International Journal of Pharmaceutics等知名期刊发表30余篇SCI论文，申请了10余项专利。于2023年荣获北京市大兴区“领军人才”和2022年重庆市“重庆英才”等多项荣誉。
微针经皮给药及其生物医学应用
1.中科院STS重点项目：聚合物微针给药技术生产工艺研发及应用
2.开放型项目：药械组合型替尔泊肽缓释微针的开发研究；基于多通路治疗色素沉积的微针制剂研制及调控机理研究；基于氧化石墨烯电热膜的透皮贴剂的研制；透皮给药微针技术专利微导航等
3.企业横向项目：基于微针贴片技术的产业化研究
1、Xing M. Z., Wang X., Zhao L. C., Zhou Z. Q., Liu H., Wang B. R., Cheng A. G., Zhang S. H*., Gao Y. H*; Novel dissolving microneedles preparation for synergistic melasma therapy: Combined effects of tranexamic acid and licorice extract. , International Journal of Pharmaceutics , 2021, 600:/，https://doi.org/10.1016/j.ijpharm.2021.120406，共同通讯作者
2、Cheng A. G., Sun W. T., Xing M. Z., Zhang S. H*., Gao Y. H.; The hygroscopicity of polymer microneedles on the performance of dissolving behavior for transdermal delivery, International Journal of Polymeric Materials and Polymeric Biomaterials , 2022, 71:/，https://doi.org/10.1080/00914037.2020.1798442，唯一通讯作者
3、Xing M. Z., Liu H., Meng F. D., Ma Y. N., Zhang S. H*., Gao Y. H*. ; Design and evaluation of complex polypeptide-loaded dissolving microneedles for improving facial wrinkles in different areas. Polymers, Polymers , 2022, 14:/，https://doi.org/10.3390/polym14214475，共同通讯作者
4、Xing M. Z., Zhang S. H*., Ma Y. N., Chen Y. Z., Yang G. Z., Zhou Z. Q., Gao Y. H*.; Preparation and evaluation of dissolving microneedle loaded with azelaic acid for acne vulgaris therapy, Journal of Drug Delivery Science and Technology, 2022, 75:/，https://doi.org/10.1016/j.jddst.2022.103667，共同通讯作者
5、Cheng A., Zhang S. H*., Wang B. R., Gao Y. H*; Layered dissolving microneedle containing a three-drug combination on the treatment of hypertrophic scar. , Journal of Drug Delivery Science and Technology , 2024, 95:/，https://doi.org/10.1016/j.jddst.2024.105572，共同通讯作者
6、Peng X. L., Yan C. X., Fan N. Q., Sun C. G., Zhang S. H*., Gao Y. H*.; Novel molecular weight gradient hyaluronate dissolving microneedles for sustained intralesional delivery and photodynamic activation of hematoporphyrin in port-wine stain therapy, Polymers , 2025, 17:/，https://doi.org/10.3390/polym17091238，共同通讯作者
7、Wang B. R., Zhang S. H*., Cheng A. G., Yan J., Gao Y. H*; Soluble polymer microneedles loaded with interferon alpha 1b for treatment of hyperplastic scar, Polymers, 2023, 15:/，https://doi.org/10.3390/polym15122621，共同通讯作者
8、Yan C. X., Xing M. Z., Zhang S. H*., Gao Y. H*.; Clinical development and evaluation of a multi-component dissolving microneedle patch for skin pigmentation disorders, Polymers, 2023, 15:/，[9].https://doi.org/10.3390/polym15153296，共同通讯作者
9、Wang B. R., Zhang S. H*., Zhao X. Y., Lian J., Gao Y. H. ; Preparation, characterization, and in vivo evaluation of levonorgestrel-loaded thermostable microneedles., Drug Delivery and Translational Research , 2022, 12:944-956，https://doi.org/10.1007/s13346-021-01057-7，唯一通讯作者
10、He M. L., Yang G. Z., Zhao X. Y., Zhang S. H*., Gao Y. H*. ; Intradermal implantable plga microneedles for etonogestrel sustained release, Journal of Pharmaceutical Sciences , 2019, 109:1958-1966，https://doi.org/10.1016/j.xphs.2020.02.009，共同通讯作者
1、张锁慧, 北京市大兴区领军人才奖, 2023
2、张锁慧，重庆市长寿区“重庆英才”人才奖，2022年
3、高云华，张锁慧, 科技成果转化奖, 中国科学院北京分院, 二等奖, 2018
人才队伍