• 姓名: 张洪艳
  • 性别: 女
  • 职称: 项目研究员
  • 职务: 无
  • 学历: 博士
  • 电话: 010-82543475
  • 传真: 无
  • 电子邮件: zhanghongyan@mail.ipc.ac.cn
  • 通讯地址: 北京市海淀区中关村东路29号
    简  历:
  • 张洪艳,女,19755月出生,19997月于东北师范大学物理系,获理学学士学位;20021月于东北师范大学物理系,获教育学硕士学位;20053月于中国科学院长春光学精密机械与物理研究所,获光学博士学位,20053月至200612月,中国科学院物理所L03组从事博士后研究工作;20071月至20075月,中国科学院物理所L03组,助理研究员;20093月至今,中国科学院理化技术研究所,副研究员,硕士生导师;20138月至20145月,美国约翰霍普金斯大学医学院药物与分子科学系,访问学者。主要从事生物检测和成像(斜入射光反射差、表面等离子共振、激光扫描共聚焦等)系统建立及应用研究,超高灵敏表面等离子共振元件制备及应用研究,光电材料及器件光物理性能检测系统建立及应用研究,近红外光谱在生化检测中的应研究。Biosens. Bioelectron.,Inorg. Chem.Chem. Commun.Sensors and Actuators B: Chemical等著名国际期刊发表论文90余篇,申请发明专利26项,其中授权19项,入选2009年北京科技新星(A)类。
    社会任职:
    研究方向:
  • 生物检测和成像系统建立及应用研究;超高灵敏表面等离子共振元件制备及应用研究;光电材料及器件光物理性能检测系统建立及应用研究;近红外光谱在生化检测中的应用研究。
    承担科研项目情况:
  •   中国科学院重大装备研制项目No.YZ200740(2007年10月-2011年12月)

      国家高技术研究发展计划(863计划)项目No.2009AA03Z318(2009年5月-2011年12月)

      国家自然基金面上项目 No.60978034(2011年1月-2012年12 月)

      中国科学院仪器设备功能开发技术创新项目 No.YZ2010018(2011年1月-2012年12 月

      中国科学院科研装备研制项目 No.YZ201235(2012年7月-2015年7月)

      国家自然基金面上项目 No.61378044(2014年1月-2017年12月)

    代表论著:
  • 1. Yasi Li, Jiawei zhu, Hongyan Zhang,*, Weimin Liu, Jiechao Ge, Jiasheng Wu, Pengfei Wang, High sensitivity gram-negative bacteria biosensor based on a small-molecule modified surface plasmon resonance chip studied using a laser scanning confocal imaging-surface plasmon resonance system, Sensors and Actuators B: Chemical, Accepted, DOI: 10.1016/j.snb.2017.12.042 (通讯作者, SCI,IF=5.401)

    2. Yangyang He, Zhanxian Li,*, Qingyan Jia, Bingjie Shi, Hongyan Zhang,*, Liuhe Wei, Mingming Yu, Ratiometric fluorescent detection of acidic pH in lysosome with carbon nanodots, Chinese Chemical Letters, 2017, 28, 1969-1974 (通讯作者,SCI,IF=1.932)

    3. Xingjiang Liu, Yuanan Su, Huihui Tian, Lei Yang, Hongyan Zhang*, Xiangzhi Song* and James W. Foley, A Ratiometric Fluorescent Probe for Lysosomal pH Measurement and Imaging in Living Cells Using Single-Wavelength Excitation, Analytical Chemistry, 2017, 89, 7038–7045 (通讯作者, SCI, IF=6.32)  

    4.  Haixia Li,?,Hao Dong,?,Mingming Yu,?Chunxia Liu,Zhanxian Li,*,?Liuhe Wei,Ling-Dong Sun,*,?and Hongyan Zhang*§, NIR ratiometric luminescence detection of pHfluctuation in living cells with hemicyanine derivative-assembled upconversion nanophosphors,?Analytical Chemistry, 2017, 89, 8863-8869 (通讯作者, SCI, IF=6.32)

    5. Mingming Yu *, Weiwei Du, Haixia Li, Hongyan Zhang*, Zhanxian Lia*,Near-infrared ratiometric fluorescent detection of arginine in lysosome with a new hemicyanine derivative, Biosensors and Bioelectronics, 2017, 92, 385–389 (通讯作者, SCI, IF=7.78)

    6. Zhanxian Li , Wenying Zhang,  Chunxia Liu,Mingming Yu ,  Hongyan Zhang,*, Liang Guo, Liuhe Wei, A colorimetric and ratiometric fluorescent probe for hydrazine and its application in living cells with low dark toxicity, Sensors and Actuators B: Chemical,2017, 241,665–671 (通讯作者, SCI, IF=5.401)

    7. Qian Ma, ?, ? Hongyan Zhang, *, ?, ? Weimin Liu, ? Jiechao Ge, ? Jiasheng Wu, ? Shujun Wang,*, ? Pengfei Wang,Surface-enhanced Raman scattering substrate based on cysteamine-modified gold nanoparticle aggregation for highly sensitive pentachlorophenol detection, RSC Adv., 2016, 6, 85285–85292 (通讯作者, SCI, IF=3.2877)

    8. Sha Liua, Hongyan Zhang *, Weimin Liu, Qian Ma,Jiechao Ge, Jiasheng Wu, Pengfei Wang, Investigation of biological cell–small molecule interactions with a gold surface plasmon resonance sensor using a laser scanning confocal imagingsurface plasmon resonance system, RSC Adv., 2016, 6, 65930–65935 (通讯作者,SCI,IF=3.2877)

    9. Mingming Yu * , Weiwei Du , Wan Zhou , Haixia Li , Chunxia Liu , Liuhe Weia , Zhanxian Lia, **, Hongyan Zhang, *** , A 1,8-naphthalimide-based chemosensor with an off-on fluorescence and lifetime imaging response for intracellular Cr3+ and further for S2-, Dyes and Pigments,2016, 126, 279-285 (通讯作者, SCI, IF=4.02)

    10. Shuang Liu, Hongyan Zhang, Jun Dai, Shaohui Hu, Ignacio Pino, Dan Eichinger, Huibin Lyu*, Heng Zhu*. Characterization of  mono-specific monoclonal antibodies using oblique-incidence reflectivity difference approach, mAbs, 2015, 7, 110--119  (共同第一作者,IF=4.726)

    11. Wenqiang Chen , Song Chen , Bingjiang Zhou, Hongbo Wang , Xiangzhi Song*, Hongyan Zhang , *, Highly selective red-emitting H2S fluorescent probe with a large Stokes shift,Dyes and Pigments,2015, 113, 596-601 (通讯作者,IF=3.468)

    12.Hongyan Zhang, Lingqiang Meng, Weimin Liu, Pengfei Wang, Online evaluation system for the photo-physical properties of organic photoelectricmaterials and device integrated with the device fabrication instrument, Proc. SPIE. 9684, 2015, 96841F(EI)

    13.ShaLiu,HongyanZhang*,WeiminLiu,Pengfeiang,Ultrasensitive and selective detection of mercury (II) in serum based on the goldfilm sensor using a laser scanning confocal imaging-surface plasmon resonancesystem in real time, Proc. SPIE. 9677, 2015, 96770I (EI)

    14. Yan Fu, Xiu-Juan Jiang,Yan-Yan Zhu, Bing-Jiang Zhou, Shuang-Quan Zang,*Ming-Sheng Tang, Hong-Yan Zhang* and Thomas C. W. Mak, A new fluorescent probe for Al3+ based on rhodamine 6G and its application to bioimaging, Dalton Trans., 2014, 43, 2624–12632 (通讯作者, IF=4.197)

    13.  Hongyan Zhang, Liquan Yang, Bingjiang Zhou, Xueliang Wang, GuiyingLiu*, WeiminLiu*, PengfeiWang, Investigation of biological cell-protein interactions using SPR sensor through laser scanning confocal imaging-surface plasmon resonance system,SpectrochimicaActa Part A: Molecular and Biomolecular Spectroscopy, 2014, 121, 381–386 (IF=1.977)

    14. Xiu-Juan Jiang, Yan Fu, HaoTang, Shuang-QuanZang, Hong-Wei Hou, Thomas C.W. Mak, Hong-Yan Zhang*, A new highly selective fluorescent sensor for detection of Cd2+ and Hg2+ based on two different approaches in aqueous solution, Sensors and Actuators B: Chemical, 2014, 190, 844–850 (通讯作者, IF=3.535)

    15.  Hongyan Zhang, Liquan Yang, Bingjiang Zhou, Weimin Liu, Jiechao Ge, Jiasheng Wu, Ying Wang, Pengfei Wang, Ultrasensitive and selective gold film-based detection of mercury(II) in tap water using a laser scanning confocal imaging-surface plasmon resonance system in real time, Biosens. Bioelectron., 2013, 47, 391–395 (IF=5.437)

    获奖及荣誉:
  •  2009年入选北京市科技新星计划(A