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  • 姓名： 李雷
  • 性别： 女
  • 职称： 研究员（自然科学）
  • 职务： 
  • 学历： 博士研究生
  • 电话： 010-82543766
  • 传真： 
  • 电子邮件： lileilei@mail.ipc.ac.cn
  • 通讯地址： 北京市海淀区中关村东路29号
    简　　历：

  • 教育经历
    2003-09至2009-07，清华大学医学院生物医学工程专业，博士
    1999-09至2003-07，清华大学热能工程系热能与动力工程专业，学士
    工作经历
    2012-04至今，中国科学院理化技术研究所，历任助理研究员、副研究员、研究员
    2015-09至2016-12，美国哈佛大学医学院及其附属麻省总医院，访问学者
    2010-06至2010-12，日本东北大学原子分子材料科学高等研究机构，研究助理
    2009-06至2012-04，中国科学院半导体研究所，博士后

    社会任职：
    研究方向：
  • 面向生命健康领域重大需求，开展生物医学微器件的设计制造和应用研究：
    1. 液态金属神经-电界面：基于液态金属材料的柔性可拉伸神经电极和神经导管，柔性电子与电子皮肤等。
    2. 微流控芯片与器官芯片：模拟体内环境，构建仿生平台，研究环境、细胞、药物之间的相互作用；
    3. 微流体技术与液态金属材料、微纳加工技术、组织工程学等的跨学科研究。
    承担科研项目情况：
  • 1. 国家级项目，多通道液态金属柔性神经电极研发；
    2. 国家重点实验室项目，仿生纳米针尖制造及其抗菌机理研究；
    3. 国自然面上项目，多层液滴微流控芯片提高微生物可培养性的研究；
    4. 国自然面上项目，量子点结合微流控芯片识别循环肿瘤细胞的光学检测方法研究；
    5. 中科院重点部署项目，微流控芯片技术检测循环肿瘤细胞在肺癌中的应用研究；
    6. 北京市教委，基于微流体技术的体外血管系统构建；
    7. 所级项目，小口径人工血管构建关键技术探索。
    代表论著：

  • [1] 桂林，高猛，叶子，李雷，液态金属微流体学，上海科学技术出版社，2021。
    [2] Huan Hu and Lei Li, Micro/nanofabrication of IVD/POCT Biosensors, Bentham Science Publishers, Frontiers in Nanobiotechnology Vol. 1, 2020.
    Selected papers:
    [1] Xilong Zhang, Zhongshan Deng*, Huize Song, Minghui Guo and Lei Li*. Liquid Metal Electromagnetic Wave Shielding and Absorbing (EWSA) Film for Solving Electromagnetic Interference in Flexible Sensor Devices. Science China-Materials, 2024.
    [2] Xilong Zhang, Chang Liu, Rongyu Tang, Weichen Feng, Jingru Gao, Bingjie Wu, Zhongshan Deng, Jing Liu*, Lei Li*. Liquid metal neuro-electrical interface, Soft Sci, 2024, 4, 23. (Invited review)
    [3] Sicong Liu, Lei Li*, Chanyuan Jiang, Qianyu Wang, Zhongshan Deng*. Synergistic injection of the thermosensitive hydrogel and bismuth-based alloy bone cement for orthopaedic repair. Science China-Technological Sciences, 2024, 67, 2153.
    [4] Qingyue Guo, Lei Li*, Guanyue Gao, Qi Zhao, Xia Huang, Hao Wang, Bingxin Liu, Jinfang Zhi*. Nanodiamonds inhibit the proliferation and migration of endothelial cells in a tumor/endothelial cells co-culture microfluidic system. Carbon, 2024, 218, 118671.
    [5] Siyuan Zhou, Lei Li*, Enzehua Xie, Meixi Li, Jianhua Cao, Xiubin Yang*, Dayong Wu*. Small-diameter PCL/PU Vascular Graft Modified with Heparin-aspirin Compound for Preventing the Occurrence of Acute Thrombosis. International Journal of Biological Macromolecules, 2023, 249, 126058.
    [6] Xilong Zhang, Lei Li*, Zhongshan Deng*. Liquid Metal-Based Flexible Bioelectrodes for Management of In-Stent-Restenosis: Potential Application. Biosensors, 2023, 13(8), 795.
    [7] Xilong Zhang#, Bingxin Liu#, Jingru Gao, Yiran Lang, Xiaodong Lv, Zhongshan Deng, Lin Gui, Jing Liu, Rongyu Tang*, Lei Li*. Liquid Metal-Based Electrode Array for Neural Signal Recording. Bioengineering, 2023, 10(5), 578.
    [8] Meixi Li, Dayong Wu*, Rongyu Tang, Siyuan Zhou, Weihua Liang, Jing Liu, Lei Li*. Liquid metal integrated PU/CNT fibrous membrane for human health monitoring. Front. Bioeng. Biotechnol. 2023, 11, 1169411.
    [9] Feng Tian#, Meixi Li#, Shaoxiong Wu, Lei Li*, Huan Hu*. A hybrid and scalable nanofabrication approach for bio-inspired bactericidal silicon nanospike surfaces. Colloids and surface B: Biointerfaces, 2023, 222, 113092.
    [10] Rongyu Tang#, Chenglin Zhang#, Bingxin Liu, Chanyuan Jiang, Lei Wang, Xuerui Zhang, Qiang Huang, Jing Liu*, Lei Li*. Towards an artificial peripheral nerve: Liquid metal-based fluidic cuff electrodes for long-term nerve stimulation and recording. Biosensors and Bioelectronics, 2022, 216, 114600.
    [11] Chenglin Zhang, Lei Li*, Zhaobing Li, Hao Chang, Jing Liu*. Investigation on the spreading and solidification of supercooled gallium droplets during impact. International Journal of Heat and Mass Transfer, 2022, 183, 122142.
    [12] Feng Tian, Meixi Li, Dong Pu, Bo Yao, Yang Xu, Dayong Wu, Lei Li*, Huan Hu*. A versatile and environmentally friendly microfabrication process for producing micro-basin array for single cell analysis, IEEE MEMS 2021 Virtual Conference.
    [13] Meixi Li, Lei Li*, Siyuan Zhou, Jianhua Cao, Weihua Liang, Ye Tian, Xuetao Shi, Xiubin Yang, Dayong Wu*. A biomimetic orthogonal-bilayer tubular scaffold for the co-culture of endothelial cells and smooth muscle cells. RSC Adv., 2021, 11, 31783.
    [14] Qingyue Guo, Lei Li*, Guanyue Gao, Runze Liu, Yasuaki Einaga, Jinfang Zhi*. Nanodiamonds Inhibit Cancer Cell Migration by Strengthening Cell Adhesion: Implications for Cancer Treatment. ACS Applied Materials & Interfaces, 2021, 13, 9620.
    [15] Lei Li#, Hao Chang#, Yong Nie, Meixi Li, Yi Hou, Wei Rao*. Superior Antibacterial Activity of Gallium based Liquid Metal Due to Ga3+ Induced Intracellular ROS Generation, Journal of Materials Chemistry B, 2021, 9, 85. (Cover story).
    [16] Qiangqiang Tang, Xiaoyu Li, Chen Lai, Lei Li*, Hongkai Wu, Yingjun Wang, Xuetao Shi*. Fabrication of a hydroxyapatite-PDMS microfluidic chip for bone-related cell culture and drug screening, Bioactive Materials, 2021, 6, 169.
    [17] Lei Li#, Cheng Wang#, Yong Nie, Bo Yao, Huan Hu*. Nanofabrication Enabled Lab-on-a-Chip Technology for the Manipulation and Detection of Bacteria, Trends in Analytical Chemistry, 2020, 127, 115905.
    [18] Chenglin Zhang, Lei Li*, Xiaohu Yang, Jintao Shi, Lin Gui, Jing Liu*. Study on the Nucleating Agents for Gallium to Reduce its Supercooling. International Journal of Heat and Mass Transfer, 2020, 148, 119055.
    [19] Mengjia Dou#, Yazhou Li#, Ziqiao Sun, Lei Li*, Wei Rao*. L-Proline feeding for augmented freeze tolerance of Camponotus Japonicus Mayr. Science Bulletin, 2019, 64(23), 1795.
    [20] Lei Li, Kurtulus Gokduman*, Aslihan Gokaltun, Martin L. Yarmush, O. Berk Usta*. A microfluidic 3D hepatocyte chip for hepatotoxicity testing of nanoparticles. Nanomedicine, 2019, 14(16), 2209.
    [21] Lei Li, Feng Tian, Hao Chang, Jie Zhang, Cheng Wang, Wei Rao, Huan Hu*. Interactions of Bacteria with Monolithic Lateral Silicon Nanospikes Inside a Microfluidic Channel. Frontiers in Chemistry, 2019, 7, 483.
    [22] Yuyao Wei, Ziqiao Sun*, Haohui Ren, and Lei Li*. Recent Advances in Microdroplet Generation Methods. Chinese Journal of Analytical Chemistry, 2019, 47(6), 795.
    [23] Xiaoqing Lv, Lei Li*, Hongmei Chen, Peng Chen*, Jing Liu. Advances in isolating circulating tumor cells with microfluidic chips. Prog. Biochem. Biophys., 2015, 42(4), 301.
    [24] Lei Li, Xiaoqing Lv, Serge Ostrovidovc, Xuetao Shi*, Ning Zhang*, Jing Liu. Biomimetic microfluidic device for in vitro antihypertensive drug evaluation. Molecular Pharmaceutics, 2014, 11(7), 2009-2015.
    [25] Lei Li, Yang Yang, Xuetao Shi, Hongkai Wu*, Hongda Chen*, Jing Liu. A microfluidic system for the study of the response of endothelial cells under pressure. Microfluidics and Nanofluidics, 2014, 16(6), 1089.
    [26] Xuetao Shi#*, Lei Li#, Serge Ostrovidov, Yiwei Shu, Ali Khademhosseini, Hongkai Wu*. Stretchable and micropatterned membrane for osteogenic differentation of stem cells. ACS Applied Materials & Interfaces, 2014, 6(15), 11915.
    [27] Lei Li*, Xiaoqing Lv, Hu Guo*, Xuetao Shi, Jing Liu. On-chip direct freezing and thawing of mammalian cells. RSC Advances, 2014, 4, 34443.
    [28] Lei Li, Jing Su, Jing Li, Fei Peng, Hongkai Wu*, Datian Ye*, Hongda Chen. A microfluidic platform for osmotic fragility test of red blood cells. RSC Advances, 2012, 2, 7161.
    [29] Lei Li, Yong Nie, Xuetao Shi, Hongkai Wu*, Datian Ye*, Hongda Chen. Partial transfection of cells using laminar flows in microchannels. Biomicrofluidics, 2011, 5(3), 36503.
    [30] Lei Li, Yong Nie, Datian Ye*, Guoping Cai. An easy protocol for on-chip transfection of COS-7 cells with a cationic lipid-based reagent. Lab on a Chip, 2009, 9, 2230–2233.

    获奖及荣誉：
  • 2014 中国制冷学会技术发明奖一等奖
    2013 中国科学院科技成果在北京转化先进团队特等奖
    2005 国际生物医学工程联合会杰出中国学生奖（全国共6名）
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地址：中国.北京